The action of DOLO-META B can be attributed to its components. Diclofenac Sodium is a non-steroidal anti-inflammatory agent that possesses analgesic and anti-pyretic activities. Its mode of action, like that of other non-steroidal anti-inflammatory agent is not known. However, its therapeutic action is not due to pituitary-adrenal stimulation but may be from the inhibitory action in the synthesis of prostaglandin, It exhibits very marked anti-rheumatic, anti-inflammatory, analgesic and anti-pyrctic properties and is thus suitable for use in inflammatory and degenerative rheumatic disease as well as for the treatment of post-traumatic inflammation and swellings. In patients treated for rheumatoid arthritis and osteoarthritis, the anti-inflammatory action has been shown by reduction in joint swellings, reduction in pain, also reduction in duration of morning sickness. Thiamine (Vit. B1), Vit. B12, Pyridoxine (Vit B6) is used in treating neurological symptoms such as peripheral neuritis.